Formulation:Article Title: Curcuminoids as Anticancer Drugs: Pleiotropic Effects, Potential for Metabolic Reprogramming and Prospects for the Future.
Article Snippet: .. Major Cellular Findings Cell Line Formulation Solvent Ref. Cellular viability ↓, proliferation ↓, necrosis ↑, apoptosis ↑ Primary Human Dermal Fibroblast (ATCC®PCS-201-012TM) Curcumin (10 μM/24 h) * DMSO [93] Lack of apoptosis Primary cultures of: rat hepatocytes, lymphocytes and skin fibroblasts, Chinese hamster ovary cells Curcumin (50 μM/24 h) ** Ethanol [94] Reversible inhibition (4–24 h) of cell cycle progression without apoptosis Normal Human Mammary Epithelial Cell Clonetics® Curcumin (10 mM/48 h) ** Unknown [95] Lack of apoptosis Human lung epithelial (Beas2b) and prostate epithelial (PrEC) cells Curcumin (30 μM/48 h) ** DMSO [96] No change in cellular viability Normal human gingival fibroblasts (HGF) and normal human oral keratinocytes (OKs) PLGA nanoparticles loaded with curcumin (80 μM/48 h) * - [97] Lack of apoptosis Immortalized cell lines: Vero (kidney of a normal adult African green monkey); F111 (rat) Curcumin (50 μM/24 h) ** Ethanol [94] No change in cellular viability Immortalized human fibroblasts WI-38 Curcumin (50 μM/72 h) ** Ethanol [98] Cellular viability ↓ Immortalized embryonic human kidney cell line HEK293 Curcumin (20 μM/72 h) * DMSO [96] Minimal change in cellular viability (more than 90% of viable cells) Non-tumorigenic mesothelial rat cell line F1-0e Curcumin (75 μM/4 h and 50 μM/6 h) DMSO [63] * minimal effective concentration and exposure time; ** maximal applied concentration and exposure time. ..
Solvent:Article Title: Curcuminoids as Anticancer Drugs: Pleiotropic Effects, Potential for Metabolic Reprogramming and Prospects for the Future.
Article Snippet: .. Major Cellular Findings Cell Line Formulation Solvent Ref. Cellular viability ↓, proliferation ↓, necrosis ↑, apoptosis ↑ Primary Human Dermal Fibroblast (ATCC®PCS-201-012TM) Curcumin (10 μM/24 h) * DMSO [93] Lack of apoptosis Primary cultures of: rat hepatocytes, lymphocytes and skin fibroblasts, Chinese hamster ovary cells Curcumin (50 μM/24 h) ** Ethanol [94] Reversible inhibition (4–24 h) of cell cycle progression without apoptosis Normal Human Mammary Epithelial Cell Clonetics® Curcumin (10 mM/48 h) ** Unknown [95] Lack of apoptosis Human lung epithelial (Beas2b) and prostate epithelial (PrEC) cells Curcumin (30 μM/48 h) ** DMSO [96] No change in cellular viability Normal human gingival fibroblasts (HGF) and normal human oral keratinocytes (OKs) PLGA nanoparticles loaded with curcumin (80 μM/48 h) * - [97] Lack of apoptosis Immortalized cell lines: Vero (kidney of a normal adult African green monkey); F111 (rat) Curcumin (50 μM/24 h) ** Ethanol [94] No change in cellular viability Immortalized human fibroblasts WI-38 Curcumin (50 μM/72 h) ** Ethanol [98] Cellular viability ↓ Immortalized embryonic human kidney cell line HEK293 Curcumin (20 μM/72 h) * DMSO [96] Minimal change in cellular viability (more than 90% of viable cells) Non-tumorigenic mesothelial rat cell line F1-0e Curcumin (75 μM/4 h and 50 μM/6 h) DMSO [63] * minimal effective concentration and exposure time; ** maximal applied concentration and exposure time. ..
Inhibition:Article Title: Curcuminoids as Anticancer Drugs: Pleiotropic Effects, Potential for Metabolic Reprogramming and Prospects for the Future.
Article Snippet: .. Major Cellular Findings Cell Line Formulation Solvent Ref. Cellular viability ↓, proliferation ↓, necrosis ↑, apoptosis ↑ Primary Human Dermal Fibroblast (ATCC®PCS-201-012TM) Curcumin (10 μM/24 h) * DMSO [93] Lack of apoptosis Primary cultures of: rat hepatocytes, lymphocytes and skin fibroblasts, Chinese hamster ovary cells Curcumin (50 μM/24 h) ** Ethanol [94] Reversible inhibition (4–24 h) of cell cycle progression without apoptosis Normal Human Mammary Epithelial Cell Clonetics® Curcumin (10 mM/48 h) ** Unknown [95] Lack of apoptosis Human lung epithelial (Beas2b) and prostate epithelial (PrEC) cells Curcumin (30 μM/48 h) ** DMSO [96] No change in cellular viability Normal human gingival fibroblasts (HGF) and normal human oral keratinocytes (OKs) PLGA nanoparticles loaded with curcumin (80 μM/48 h) * - [97] Lack of apoptosis Immortalized cell lines: Vero (kidney of a normal adult African green monkey); F111 (rat) Curcumin (50 μM/24 h) ** Ethanol [94] No change in cellular viability Immortalized human fibroblasts WI-38 Curcumin (50 μM/72 h) ** Ethanol [98] Cellular viability ↓ Immortalized embryonic human kidney cell line HEK293 Curcumin (20 μM/72 h) * DMSO [96] Minimal change in cellular viability (more than 90% of viable cells) Non-tumorigenic mesothelial rat cell line F1-0e Curcumin (75 μM/4 h and 50 μM/6 h) DMSO [63] * minimal effective concentration and exposure time; ** maximal applied concentration and exposure time. ..
Concentration Assay:Article Title: Curcuminoids as Anticancer Drugs: Pleiotropic Effects, Potential for Metabolic Reprogramming and Prospects for the Future.
Article Snippet: .. Major Cellular Findings Cell Line Formulation Solvent Ref. Cellular viability ↓, proliferation ↓, necrosis ↑, apoptosis ↑ Primary Human Dermal Fibroblast (ATCC®PCS-201-012TM) Curcumin (10 μM/24 h) * DMSO [93] Lack of apoptosis Primary cultures of: rat hepatocytes, lymphocytes and skin fibroblasts, Chinese hamster ovary cells Curcumin (50 μM/24 h) ** Ethanol [94] Reversible inhibition (4–24 h) of cell cycle progression without apoptosis Normal Human Mammary Epithelial Cell Clonetics® Curcumin (10 mM/48 h) ** Unknown [95] Lack of apoptosis Human lung epithelial (Beas2b) and prostate epithelial (PrEC) cells Curcumin (30 μM/48 h) ** DMSO [96] No change in cellular viability Normal human gingival fibroblasts (HGF) and normal human oral keratinocytes (OKs) PLGA nanoparticles loaded with curcumin (80 μM/48 h) * - [97] Lack of apoptosis Immortalized cell lines: Vero (kidney of a normal adult African green monkey); F111 (rat) Curcumin (50 μM/24 h) ** Ethanol [94] No change in cellular viability Immortalized human fibroblasts WI-38 Curcumin (50 μM/72 h) ** Ethanol [98] Cellular viability ↓ Immortalized embryonic human kidney cell line HEK293 Curcumin (20 μM/72 h) * DMSO [96] Minimal change in cellular viability (more than 90% of viable cells) Non-tumorigenic mesothelial rat cell line F1-0e Curcumin (75 μM/4 h and 50 μM/6 h) DMSO [63] * minimal effective concentration and exposure time; ** maximal applied concentration and exposure time. ..
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